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Dextran Sulfate Sodium Salt

CAS No.
9011-18-1
Chemical Name:
Dextran Sulfate Sodium Salt
Synonyms
DEXTRAN SULFATE SODIUM;DEXTRAN SULFATE;SODIUM DEXTRAN SULFATE;Dextran sulfate sodium salt - MW 9,000-11,000 - from Leuconostoc spp;ds-m-1;DEXTRAN SULPHATE;Dextran sulfate sodium salt, M.W 5,000;Dextran sulfate sodium salt - MW 100,000;Dextran sulfate sodium salt - MW 4500-5500;Dextran sulfate sodium salt - MW 6,000-10,000
CBNumber:
CB9339022
Molecular Formula:
(C6H7Na3O14S3)n
Molecular Weight:
0
MOL File:
Mol file

Dextran Sulfate Sodium Salt Properties

storage temp. room temp
solubility H2O: 100 mg/mL
form powder
color White to off-white
PH pH(50g/l, 25℃)4.5~8.0
Water Solubility Soluble in water.
Merck 2951
EWG's Food Scores 1
EPA Substance Registry System Dextran, hydrogen sulfate, sodium salt (9011-18-1)

SAFETY

Risk and Safety Statements

Hazard Codes  Xi,Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36-37/39-24/25
WGK Germany  2
RTECS  HH9290000
3-10
TSCA  Yes
HS Code  39139000

Dextran Sulfate Sodium Salt price More Price(150)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S4031 Dextran Sulfate 50% Solution 9011-18-1 200ML $320 2022-05-15 Buy
Sigma-Aldrich RES2029D-A7 Dextran sulfate sodium salt PharmaGrade, Manufactured under appropriate controls for use as raw material in pharma or biopharmaceutical production, suitable for cell culture 9011-18-1 1pkg $1478 2022-05-15 Buy
Sigma-Aldrich 31404 Dextran sulfate sodium salt from Leuconostoc spp. Mr 5,000 9011-18-1 5G $54.2 2022-05-15 Buy
Sigma-Aldrich 31404 Dextran sulfate sodium salt from Leuconostoc spp. Mr 5,000 9011-18-1 25g $259 2022-05-15 Buy
Sigma-Aldrich 265152-M Dextran Sulfate, Sodium Salt, Molecular Biology Grade - CAS 9011-18-1 - Calbiochem Used to accelerate hybridization of DNA probes to immobilized nucleic acids. 9011-18-1 265152-10GM $82.6 2022-05-15 Buy
Product number Packaging Price Buy
S4031 200ML $320 Buy
RES2029D-A7 1pkg $1478 Buy
31404 5G $54.2 Buy
31404 25g $259 Buy
265152-M 265152-10GM $82.6 Buy

Dextran Sulfate Sodium Salt Chemical Properties,Uses,Production

Description

Dextran sulfate (dextran hydrogen sulfate, sodium salt) has been tested as a potential substitute for heparin in anticoagulant therapy. Following studies by Ingelman, Walton and Ricketts explored the anticoagulant properties of a wide range of dextran sulfates (Mw 7000 to 458000) and established that the lowest molecular weight products displayed the highest anticoagulant properties. However, at best this only represented 15% of heparin's activity.
With the introduction of low-dose heparin therapy for thrombosis prophylaxis in the 70's, interest in low molecular weight polyanions has been rekindled and reports on interactions with individual enzyme/inhibitor systems in the coagulation cascade have appeared.
Dextran sulfate immobilized on cellulose has been found to remove LDL cholesterol preferentially during plasmaphoresis.
Its wide spectrum of biological properties has attracted the attention of many scientists. The reports may be grouped according to the following biological effects.

  • Enzyme inhibition, activation and release
  • Adjuvant effect on immune response
  • Cellular interactions and response
  • Effect on virus infectivity

Uses

  1. Dextran sulfate is a polyanionic derivative of dextran produced by esterification of Dextran with chlorosulphonic acid. The sulfur content is approximately 17% which corresponds to an average of 1.9 sulfate groups per glucosyl residue of the dextran molecule. Dextran sulfate sodium (DSS) is the sodium salt which is a white to off-white powder freely soluble in water and salt solutions to form a stable, clear solution. The high purity and reproducible quality enables its application in pharmaceuticals and biotechnology industry.
  2. Dextran sulfate is used asa nucleic acid hybridization accelerant. The polyanionic character of Dextran sulfate helps to approximate nucleic acid strands, increasing their effective concentration to each other and promoting hybridization. Dextran sulfate also demonstrates a sequestering interaction with proteins, presumably through hydrogen-bonding between the sulfate groups and amine groups of the protein that generates an insoluble complex. The ability of the polymer to precipitate fibrinogen and low-density lipoproteins from plasma solutions has been used for analysis and for anticoagulant applications. Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used to study Colitis (Inflammatory Bowel disease) as well as an antiviral as agent.Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate.
  3. Dextran sulfate sodium shows immunologically relevant activities: enhancement and suppression of humoral immunity, polyclonal activation of B-lymphocytes, stimulating even immature B cells, changes in thymocyte reactivity to lectins, enhancement/suppression of cell-mediated immune responses. Precipitates LDL and VLDL lipoproteins - in the presence of magnesium ions, dextran sulfate precipitates low-density lipoproteins from human serum leaving the high-density lipoproteins in the supernatant. Removal of lipoproteins by dextran sulfate precipitation may be useful in the purification of other materials such as beta 2 glycoprotein.

Toxicity

The toxicity of these products had been recognized at an early stage. Nevertheless, a low molecule weight fraction with Mw 7000 and S, 16% was considered to be qualitatively similar to heparin. Preliminary clinical trials were unfortunately discouraging and revealed severe adverse reactions, notably, stiff and painful joints, skin eruption, loss of hair and gastro-intestinal symptoms. In chronic toxicity studies in animals, retardation in weight gain and osteoporosis with spontaneous fractures were observed. It should be noted that the doses in the clinical trials corresponded to 1.3 g/day, which is approximately tenfold that used in current heparin therapy.
More recently attention has been focussed on the toxicity of orally administered substance. Supplements of 0.25% and 0.5% for 82 weeks in rats did not increase the incidence of infection or tumours. Higher doses (1–10%) resulted in mortality and tumours. Apart from dosage, the toxicity is also dependent on Mw. Adsorption studies in the gut using a wide range of dextran sulfates (3000–200000) suggest only a small proportion of the dose is absorbed. Intravenous administration has also been investigated. The inhibition of metastasis by dextran sulfate (Mw 6–7 x 10 3 , DS approx. 2) has been tested clinically but the 5 year survival rate in lung cancer was not improved. Tests for mutagenicity and cytogenicity of low MW dextran sulfate proved negative.

Chemical Properties

White to off-white powder

Uses

Clinical reagent (HDL cholesterol determination).

Uses

Clinical studies indicate a possible capacity of dextran sulfate to reduce edema. It is cited as a binder and skin conditioner.

Uses

Dextran sulfate sodium salt Leuconostoc spp has been used:
  • as a standard to perform polyacrylamide-gel electrophoresis for carbohydrates (C-PAGE)(59) and agarose gel electrophoresis(60)
  • for RNA sequential probing of targets (SPOTs) imaging(61)
  • as a component of 1% injection buffer(62)

General Description

Dextran sulfate is a sulfated polysaccharide, which is negatively charged. It is produced by the esterification of dextran with chlorosulphonic acid. Dextran is used to treat hemorrhage, burns, surgery and trauma. It improves blood flow and prevents erythrocyte aggregation. Dextran lowers the risk of thrombosis and postoperative pulmonary emboli. It is a ribonuclease inhibitor. Dextran sulfate exhibits antiviral, anticoagulant and adjuvant properties.

Biochem/physiol Actions

Dextran is a mixture of glucose polymers of varying size and geometry.Dextran in the form of dextran sulphate sodium acts as an anticoagulant. Dextran interferes with blood clot formation by acting on blood coagulation factors and the function of platelets. It prolongs the time required for formation of the clot and decreases the maximum clot strength. The disturbance of homeostasis by dextran may cause increased bleeding, colitis and kidney failure.

Dextran Sulfate Sodium Salt Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 295)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 info@dakenchem.com China 16666 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 info@tianfuchem.com China 22021 55
Herbon International Holdings Company Limited
(+86) 0762 3499803 CHINA 3 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714 fandachem@gmail.com China 9382 55
Shanxi Naipu Import and Export Co.,Ltd
+86-13734021967 13734021967 kaia@neputrading.com CHINA 1011 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038 zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29959 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293 sales@sdzschem.com CHINA 2940 58
Jinan Carbotang Biotech Co.,Ltd.
+8615866703830 figo.gao@foxmail.com China 3639 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 +86-19930503282 alice@crovellbio.com China 5953 58

Related articles

View Lastest Price from Dextran Sulfate Sodium Salt manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-02-25 Dextran Sulfate Sodium Salt
9011-18-1
US $10.00 / KG 1KG 99% 500tons/month Shanxi Naipu Import and Export Co.,Ltd
2022-02-24 Dextran Sulfate Sodium Salt
9011-18-1
US $10.00 / Kg/Drum 1KG 99% 5000tons per month Wuhan Mulei New Material Technology Co. Ltd
2021-07-13 Dextran sulfate sodium
9011-18-1
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
asuro dexnon Dextran sulfate sodium salt, M.W 5,000 Dextran sulfate sodium salt, M.W 6,500-10,000 OmniPur Dextran Sulfate Sodium - CAS 9011-18-1 - Calbiochem Dextran sulfate sodium salt,Mw 40,000 Dextran sulfate sodium salt,Mw 20,000 Dextran Sulfate, Sodium Salt, Molecular Biology Grade - CAS 9011-18-1 - Calbiochem Dextran sulphate sodium salt 15,000 Dextran sulphate 500000 Dextran sulfate sodium salt - MW 100,000 Dextran sulfate sodium salt - MW 4500-5500 Dextran sulfate sodium salt - MW 6,000-10,000 Dextran sulfate sodium salt - MW 9,000-11,000 - from Leuconostoc spp Dextran,hydrogensulfate,sodiumsalt dextransodiumsulfate dextransulfateso-saltfromleuconostocssp. dextrarine dexulate ds-m-1 mds(polysaccharide) DEXTRAN SULFATE SODIUM MOLECULAR*BIOLOGY REAGENT DEXTRAN SULFATE SODIUM SALT, FROM LEUCONOSTOC SSP. DEXTRAN SULFATE SODIUM AV. MOL. WT. OF*5 00,000 DEXTRAN SULFATE SO-SALT FROM LEUCONOSTOC SSP., MR ~500000 DEXTRAN SULFATE SODIUM SALT FROM LEUCONOSTOC SSP., MW 100'000 DEXTRAN SULFATE SODIUM SALT FROM LEUCONOSTOC SPP. DEXTRAN SULFATE SODIUM AV. MOL. WT.*APPR OX. 8,000 DextranSulfate500,000Mw DEXTRANSULFATE,50%SOLUTION,STERILE,BIOTECHGRADE DEXTRANSULFATESODIUMSALT,POWDER DEXTRANSULFATESODIUMSALT,POWDER,HEAVY DEXTRANSULFATESODIUMSALT,POWDER,LIGHT extran sulfate sodium DEXTRAN SULFATE SODIUM (FROM DEXTRAN OF MW. APPROX. 2.500) DEXTRAN SULFATE SODIUM (FROM DEXTRAN OF MW. APPROX. 4.000) DEXTRAN SULFATE SODIUM (FROM DEXTRAN OF MW. APPROX. 25.000) Dextran Sulfate 2000 Dextran Sulfate 3000 Dextran Sulfate 40,000 Dextran Sulfate 50,000 Dextran sulfate 500,000 Dextran Sulfate 5000 DEXTRAN SULPHATE extrapure DEXTRAN SULFATE AV. MOL. WT. 5,000*(LALL S) Dextran sulphate sodium from leuconostoc 500,000 Dextran Sulfate 10,000 Dextran sulfate sodium salt from Dextran of Mw. Approx. 15,000 Dextran sulfate sodium salt from Dextran of Mw. Approx. 10,000 Dextran sulfate sodium salt from Dextran of Mw. Approx. 1,500 Isomalto oligosaccharide sulfate1500 Isomalto oligosaccharide sulfate3000 Dextran sulfate sodium from Dextran of Mw. Approx. 10,000 Dextran sulfate sodium from Dextran of Mw. Approx. 15,000 Dextran sulfate sodium from Dextran of Mw. Approx. 20,000 Dextran sulfate sodium from Dextran of Mw. Approx. 40,000 Dextran sulfate sodium from Dextran of Mw. Approx. 50,000 ACRYL/BIS 19:1 ULTRA PURE GRADE