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4'-Hydroxyacetophenone

4'-Hydroxyacetophenone Structure
4'-Hydroxyacetophenone structure
CAS No.
99-93-4
Chemical Name:
4'-Hydroxyacetophenone
Synonyms
4-HYDROXYACETOPHENONE;Piceol;P-HYDROXYACETOPHENONE;POB;P-HYDROXYBENZOPHENONE;ACETYLPHENOL;p-Acetylphenol;4-Hydroksyacetofenol;4-HYDROXYLACETOPHENONE;para-Hydroxyacetophenone
CBNumber:
CB7198612
Molecular Formula:
C8H8O2
Molecular Weight:
136.15
MOL File:
99-93-4.mol
MSDS File:
SDS
Request For Quotation

4'-Hydroxyacetophenone Properties

Melting point 132-135 °C(lit.)
Boiling point 147-148 °C3 mm Hg(lit.)
Density 1.109
FEMA 4330 | 4-HYDROXYACETOPHENONE
refractive index 1.5577 (estimate)
Flash point 166 °C
storage temp. Store below +30°C.
solubility methanol: 0.1 g/mL, clear
pka 8.05(at 25℃)
form Crystalline Powder
color Almost white to beige
Specific Gravity 1.109
Water Solubility 10 g/L (22 ºC)
JECFA Number 2040
BRN 774355
InChIKey TXFPEBPIARQUIG-UHFFFAOYSA-N
CAS DataBase Reference 99-93-4(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) 4-HYDROXYACETOPHENONE
EWG's Food Scores 1
NIST Chemistry Reference Acetophenone, 4'-hydroxy-(99-93-4)
EPA Substance Registry System 4-Hydroxyacetophenone (99-93-4)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS06
Signal word  Warning
Hazard statements  H302-H315-H301-H335-H319-H412
Precautionary statements  P261-P280a-P301+P310a-P405-P501a-P305+P351+P338-P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501
Hazard Codes  Xn,Xi
Risk Statements  36/37/38-22
Safety Statements  26-36/37-37/39-24/25-22-36
WGK Germany  3
RTECS  PC4959775
Hazard Note  Irritant
TSCA  Yes
HS Code  29145000
NFPA 704
1
2 0

4'-Hydroxyacetophenone price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1971 Acetaminophen Impurity E Pharmaceutical Secondary Standard; Certified Reference Material 99-93-4 100MG $388 2022-05-15 Buy
Sigma-Aldrich PHL80232 4′-Hydroxyacetophenone phyproof? Reference Substance 99-93-4 100MG $231 2022-05-15 Buy
Sigma-Aldrich BP770 4′-Hydroxyacetophenone British Pharmacopoeia (BP) Reference Standard 99-93-4 25MG $228 2022-05-15 Buy
Sigma-Aldrich 8.04311 4′-Hydroxyacetophenone for synthesis 99-93-4 100g $53.1 2022-05-15 Buy
Sigma-Aldrich 8.04311 4′-Hydroxyacetophenone for synthesis 99-93-4 250g $97.8 2022-05-15 Buy
Product number Packaging Price Buy
PHR1971 100MG $388 Buy
PHL80232 100MG $231 Buy
BP770 25MG $228 Buy
8.04311 100g $53.1 Buy
8.04311 250g $97.8 Buy

4'-Hydroxyacetophenone Chemical Properties,Uses,Production

Chemical Properties

almost white to beige crystalline powder

Chemical Properties

White to beige powder; sweet, hawthorn, balsam, mimosa aroma

Occurrence

Reported found in cloudberry, coffee, cranberry, mango, sherry, and wort.

Uses

4?-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions.

Uses

4′-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions.

Uses

p-Hydroxyacetophenone is widely used in medicine, cosmetics and industrial fields. It is a natural plant extract, which naturally exists in the stems and leaves of the Compositae plant, Artemisia annua, the roots of plants such as Artemisia annua, Rhododendron, and Panax ginseng. It has a good effect on yellow eyes caused by diseases such as hepatitis, and also has a good auxiliary effect on yellow eyes caused by various reasons. Due to its weak molecular activity, high temperature resistance, melting point of 95-97 °C and boiling point of 296 °C, it is widely used in various liquid pharmaceuticals and can prolong the shelf life of other active ingredients under high temperature conditions. It has no harm to human skin and is the safest high-temperature auxiliary active stabilizer in the pharmaceutical industry.

Preparation

Preparation by Fries rearrangement of phenyl acetate with Lewis acids
aluminium chloride
in nitrobenzene at 20–25° or at 50–60°
in chlorobenzene between 45° and 65°, sealed tube and subjected to high power microwave irradiation for 2 min only (36%)
in nitroethane at 60° (44%)
in carbon disulfide at 45° (40%)
in petroleum ether at 50° (20%)
but between 130° and 175° (40–60%)
aluminium chloride–sodium chloride mixture at 240–250° (10%)
boron trifluoride at 90° (56%)
scandium tris(trifluoromethanesulfonate), in nitromethane, at 50° (39%)
titanium tetrachloride at 90–100° (34%)
ferric chloride at 65° (25%)
zinc chloride at 125° (8%)
hydrofluoric acid, between 20° and 100° (94%)
polyphosphoric acid, between 20° and 100° (69%) (50–53%)(44%)
Nafion-XR 500, sulfonic acid type at 100°
ZSM-5, in sulfolane, at 180° (28%)
H-ZSM-5 at 400° or at 210° (6%)
H-Nu-2 at 170° (15%)
HY (Si/Al = 3) or fluorided alumina (Al2O3-F; 3 % wt. F), at 400°.

Definition

ChEBI: A monohydroxyacetophenone carrying a hydroxy substituent at position 4'.

Aroma threshold values

Floral type, medium strength odor; recommend smelling in a 10.00% solution or less.

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 5829, 1991 DOI: 10.1016/S0040-4039(00)93567-6

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Purification Methods

Crystallise it from diethyl ether, aqueous EtOH or *benzene/pet ether. [Beilstein 8 H 87, 8 IV 339.]

4'-Hydroxyacetophenone Preparation Products And Raw materials

Raw materials

PHENYL ACETATE Aluminum chloride 2'-Hydroxyacetophenone 4-Aminoacetophenone

Preparation Products

4-QUINOXALIN-2-YLPHENOL Acetaminophen 4-Hydroxystyrene Atenolol 1-(3-CHLOROMETHYL-4-HYDROXY-PHENYL)-ETHANONE
4-Benzyloxy-3-nitroacetophenone 4-Hydroxyphenethyl alcohol 1-(4-Acetyloxy)-3-((acetyloxy)methyl)phenyl)-2-bromoethanone HPG 4-Acetyloxy-3-acetyloxymethyl-(N-benzyl-N-tertbutylamino)acetophenone hydrochloride
4-Acetoxystyrene 1,1,1-Tris(4-hydroxyphenyl)ethane Micafungin Side Chain Methyl Ester 3',5'-DICHLORO-4'-HYDROXYACETOPHENONE 4-HYDROXYBENZOYLACETIC ACID METHYL ESTER
4'-PIPERIDINOACETOPHENONE 2-(4-HYDROXYPHENYL)PROPIONIC ACID
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4'-Hydroxyacetophenone Suppliers

Global( 691)Suppliers
Supplier Tel Email Country ProdList Advantage
Chengdu Yuanda Chemical Co., Ltd 		28-85356300 +8618980937689 sales@ydachem.com CHINA 94 58
Hebei Mojin Biotechnology Co., Ltd
+8618503279000 admin@hbmojin.com China 1177 58
.GZ HONESTCHEM CO.,LTD
+86-15013270415 +86-15013270415 honestchemical@foxmail.com China 246 58
Shan Dong Faster Biotechnological Co., LTD
+8615966163158 1093908296@qq.com China 1753 58
Yangzhou Model Electronic Materials Co., Ltd.
+8613761402923 sales@modeltemol.com CHINA 578 58
Henan DaKen Chemical CO.,LTD. 		+86-371-66670886 info@dakenchem.com China 16666 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1815 55
Henan Tianfu Chemical Co.,Ltd. 		0371-55170693 info@tianfuchem.com China 22021 55
Hangzhou FandaChem Co.,Ltd. 		+8615858145714 fandachem@gmail.com China 9382 55
Hefei TNJ Chemical Industry Co.,Ltd. 		0551-65418679 info@tnjchem.com China 2995 55
Supplier Advantage
Chengdu Yuanda Chemical Co., Ltd 		58
Hebei Mojin Biotechnology Co., Ltd
58
.GZ HONESTCHEM CO.,LTD
58
Shan Dong Faster Biotechnological Co., LTD
58
Yangzhou Model Electronic Materials Co., Ltd.
58
Henan DaKen Chemical CO.,LTD. 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Hefei TNJ Chemical Industry Co.,Ltd. 		55

Related articles

View Lastest Price from 4'-Hydroxyacetophenone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-06-21 4'-Hydroxyacetophenone
99-93-4
 US $5.00 / kg 10kg 99% 20tons Hebei Linwo New Material Technology Co., LTD
2022-03-23 4'-Hydroxyacetophenone
99-93-4
 US $1.00 / kg 1kg 99% 1ton Henan Guange Biotechnology Co. LTD
2022-03-17 4'-Hydroxyacetophenone
99-93-4
 US $100.00 / bag 1bag 99 500 Shanxi Naipu Import and Export Co.,Ltd

4'-Hydroxyacetophenone Spectrum

4'-Hydroxyacetophenone(99-93-4)MS4'-Hydroxyacetophenone(99-93-4)1HNMR4'-Hydroxyacetophenone(99-93-4)13CNMR4'-Hydroxyacetophenone(99-93-4)IR14'-Hydroxyacetophenone(99-93-4)IR2

99-93-4(4'-Hydroxyacetophenone)Related Search:

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1-(4-hydroxyphenyl)-ethanon 4’-hydroxy-acetophenon 4-Hydroksyacetofenol Acetophenone, p-hydroxy- Ethanone, 1-(4-hydroxyphenyl)- Hydroxyacetophenone, para HYDROXYACETOPHENONE-4 HYDROXYBENZOPHENONE-4 ACETYLPHENOL AKOS BBS-00003226 4-ACETOPHENOL 4-ACETYLPHENOL 4-BENZOYLPHENOL 4'-HYDROXYACETOPHENONE 4-HYDROXYACETOPHENONE 4-HYDROXYPHENYL METHYL KETONE 1-(4-HYDROXY-PHENYL)-ETHANONE 4'-Hydroxyacetophenone 4-Acetylphenol 4-HydraxyAcetophenone 4-HYDROXY ACETOPHENONE (p-HYDROXY ACETOPHENONE) 4'-Hydroxyacetophenone,99% 4-HYDROXYLACETOPHENONE PARA-METHYLKETOPHENOL PARA-ACETYLPHENOL Acetophenone,4'-hydroxy- D-Hydroxyacetophehone 4''-HYDROXYACETOPHENONESALBUTAMOL 4'-Hydroxyacetophenone 4'-Hydroxyacetophenone,98% Hydroxyce Tophenone Acetaminophen Impurity E LGB-HAP 2,5-dimethyl-1H-pyrazolo[1,5-a]pyrimidin-7-one Paracetamol EP Impurity E (4'-Hydroxyacetophenone) 4'-Hydroxyacetophenone IN STOCK 4'-Hydroxyacetophenone factory China 4'-Hydroxyacetophenone Factory 4-Acetylphenol Methyl p-hydroxyphenyl ketone methyl-p-hydroxyphenylketone p-Acetylphenol para-Hydroxyacetophenone Phenol, p-acetyl- p-hydroxy-acetophenon p-Hydroxyphenyl methyl ketone p-hydroxyphenylmethylketone Piceol p-Oxyacetophenone USAF kf-15 usafkf-15 POB P-HYDROXYACETOPHENONE P-HYDROXYBENZOPHENONE P-BENZOYLPHENOL P-ACETOPHENOL 1-(4-hydroxyphenyl)-1-ethanone HYDROXYACETOPHENONE, P- (RG) 4'-Hydroxyacetophene 4'-Hydroxyacetopheno