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Dihydrotachysterol

CAS No.
67-96-9
Chemical Name:
Dihydrotachysterol
Synonyms
dht2;AT-10;C06957;Dygrayl;Tachyrol;dihydral;dygratyl;parterol;HSDB3314;dht(sub2)
CBNumber:
CB2469405
Molecular Formula:
C28H46O
Molecular Weight:
398.66
MOL File:
67-96-9.mol

Dihydrotachysterol Properties

Melting point 116-120°C
alpha D22 +97.5° (chloroform)
Boiling point 461.8°C (rough estimate)
Density 0.9678 (rough estimate)
refractive index 1.5100 (estimate)
storage temp. 2-8°C
solubility Practically insoluble in water, freely soluble in acetone and hexane, sparingly soluble in ethanol (96 per cent).
pka 14.96±0.40(Predicted)
form neat
InChIKey ILYCWAKSDCYMBB-KWOSLRGBSA-N
FDA UNII R5LM3H112R
ATC code A11CC02

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  WW0600000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2936299055
Toxicity LD50 oral in mouse: 288mg/kg

Dihydrotachysterol price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D9257 Dihydrotachysterol analytical standard 67-96-9 50mg $188 2022-05-15 Buy
Sigma-Aldrich 1204000 Dihydrotachysterol United States Pharmacopeia (USP) Reference Standard 67-96-9 4x30mg $370 2022-05-15 Buy
Sigma-Aldrich Y0000544 Dihydrotachysterol European Pharmacopoeia (EP) Reference Standard 67-96-9 y0000544 $138 2022-05-15 Buy
Sigma-Aldrich Y0000482 Dihydrotachysterol for system suitability European Pharmacopoeia (EP) Reference Standard 67-96-9 y0000482 $138 2022-05-15 Buy
Usbiological 009867 Dihydro Tachysterol 67-96-9 10mg $319 2021-12-16 Buy
Product number Packaging Price Buy
D9257 50mg $188 Buy
1204000 4x30mg $370 Buy
Y0000544 y0000544 $138 Buy
Y0000482 y0000482 $138 Buy
009867 10mg $319 Buy

Dihydrotachysterol Chemical Properties,Uses,Production

Description

Dihydrotachysterol is a synthetic analog of vitamin D. It is considered as a reduction product of vitamin D2 (ergocalciferol). It stimulates bone mineralization as well as calcium and phosphorus absorption in intestine. Dihydrotachysterol has been used for the treatment of hypoparathyroidism, osteomalacia, osteoporosis, low calcium level, and kidney osteodystrophy. Though dihydrotachysterol is more expensive, dihydrotychysterol therapy is preferred as it has a more rapid onset of action (1-7 d) and a shorter time for dissipation of effect in the event of toxicity (2-3 weeks) than vitamin D2.

Pharmacodynamics

Dihydrotachysterol is hydroxylated in the liver to 25-hydroxydihydrotachysterol, which is the major circulating active form of the drug. It does not undergo further hydroxylation by the kidney and therefore is the analogue of 1,25-dihydroxyvitamin D. Dihydrotachysterol is effective in the elevation of serum calcium by stimulating intestinal calcium absorption and mobilizing bone calcium in the absence of parathyroid hormone and of functioning renal tissue. It also increases renal phosphate excretion. In contrast to parathyroid extract, dihydrotachysterol is active when taken orally, exerts a slow but persistent effect, and may be used for long periods without increasing the dosage or causing tolerance. Dihydrotachysterol is faster-acting than pharmacologic doses of vitamin D and is less persistent after cessation of treatment, thus decreasing the risk of accumulation and of hypercalcemia.

Indication

Used for the prevention and treatment of rickets or osteomalacia, and to manage hypocalcemia associated with hypoparathyroidism or pseudohypoparathyroidism. Also used for the treatment of vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis).

Uses

  1. Dihydrotachysterol is a form of vitamin D. Vitamin D is a fat-soluble vitamin and has properties of both vitamins and minerals. Vitamin D helps you to absorb calcium from what you eat. You need calcium to keep your bones strong, and to help your muscles and nerves work properly.
  2. The term Vitamin D collectively refers to a group of structurally similar chemicals and their metabolites, which includes alfacalcidol (1 α hydroxycholecalciferol), calcitriol (1,25-dihydroxychole-calciferol), cholecalciferol (Vitamin D3), dihydrotachysterol(DHT) and ergocalciferol (Vitamin D2). These agents have antirachitic properties.
  3. Dihydrotachysterol-2 (DHT-2) is a vitamin D2 analog for the Pharmaceutical industry.
  4. Dihydrotachysterol-2 is used in the prevention and treatment of several bone growth disorders such as osteoporosis. Besides this the substance is also used to treat several abnormalities of the parathyroid glands such as hypoprathyroidism.

References

  1. https://en.wikipedia.org/wiki/Dihydrotachysterol
  2. https://www.drugbank.ca/drugs/DB01070
  3. https://pubchem.ncbi.nlm.nih.gov
  4. Jack Z. Yetiv and Joseph R. Bianchine, Hypertension, Cardiovascular Disease, Analgesics, and Endocrine Disorders, 1981, ISBN 0-12-788950-7
  5. Carl P. Weiner and Kate Rope, The Complete Guide to Medications During Pregnancy and Breastfeeding, 2013, ISBN-10: 0312676468

Chemical Properties

White Solid

Originator

Hytakerol,Winthrop,US,1950

Uses

Calcium regulator. Preparation by reduction of Tachysterol. It is widely used for hypocalcemic hypoparathyroidism following surgical removal of parathyroids.

Definition

ChEBI: A hydroxy seco-steroid that is 9,10-secoergosta-5,7,22-triene substituted by a hydroxy group at position 3. A synthetic analogue of vitamin D that acts a bone density conservation agent.

Manufacturing Process

The process of isolating chemically uniform crystalline dihydrotachysterol comprises subjecting the solution of the crude hydrogenation product of tachysterol in benzine to chromatographic adsorption by means of active aluminum oxide while collecting the components having a minor tendency of being adsorbed, subjecting the said components to a repeated chromatographic adsorption and converting the components having a minor tendency of being adsorbed into its ester by treatment with acetic anhydride in pyridine solution, isolating the ester formed from the reaction mixture, subjecting its solution in benzine to chromatographic adsorption while collecting the components having a minor tendency of being adsorbed, recrystallizing these components, saponifying the crystalline ester and recrystallizing the dihydrotachysterol obtained.

brand name

Hytakerol (Sterling Winthrop).

Therapeutic Function

Blood calcium regulator

Veterinary Drugs and Treatments

DHT is used in small animals to treat hypocalcemia secondary to hypoparathyroidism or severe renal disease.

Purification Methods

Crystallise the sterol from 90% MeOH, UV: max at 242, 251 and 261nm (E1% 760, 1010 and 650) in EtOH. The acetate has m108-110o and [] +32.8o (CHCl3), UV: max at 242, 251 and 261nm (E 780, 910 and 600) in EtOH. The propionate has m 97-98o and [] +37o (CHCl3), UV: max 242, 251 and 261nm (E 750, 860 and 570) in EtOH. [Werder Hoppe Seyler's Z Physiol Chem 260 119 1939, Windaus et al. Justus Liebigs Ann Chem 499 1978 1932, Beilstein 6 III 2833, 6 IV 3994, 4161.]

Dihydrotachysterol Preparation Products And Raw materials

Global( 59)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 info@tianfuchem.com China 22021 55
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47501 58
Shanxi Xuanran Import and Export Trade Co., Ltd.
+8617735180244 mike_yan@xuanranglobal.com CHINA 4024 58
Dideu Industries Group Limited
029-88380327 +8617691182729 Service@dideu.com China 30023 58
AFINE CHEMICALS LIMITED
0571-85134551 info@afinechem.com CHINA 15558 58
InvivoChem
+1-708-3101919 sales@invivochem.net United States 6397 58
CARBOGEN AMCIS B.V. +31 318 545 767 rene.vanoosten@carbogen-amcis.com THE NETHERLANDS 10 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Chemvon Biotechnology Co., Ltd 021-50790412 info@chemvon.com China 373 57
Chemsky(shanghai)International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32358 50

View Lastest Price from Dihydrotachysterol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-30 Dihydrotachysterol USP/EP/BP
67-96-9
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
24-Methyl-9,10-secocholesta-5,7,22-trien-3β-ol 9,10-Secoergosta-5,7,22-trien-3-ol, (3β,5E,7E,10α,22E)- A.T. 10 (steroid) Dihydrotachysterol2 Tachyrol Tachysterol, dihydro- (7CI, 8CI) Tachysterol2, dihydro- (6CI) Dygrayl (1S,2E,3S)-2-[(2E)-2-[(7aR)-1-[(E,2R,5R)-5,6-Dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-3-methylcyclohexan-1-ol C06957 4 ampules) Dihydrotachysterol (30 mg/ampule (1S,3E,4S)-4-Methyl-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-Methyl-1-[(1R,2E,4R)-1,4,5-triMethyl-2-hexen-1-yl]-4H-onden-4-ylidene]ethylidene]cyclohexanol Dihydrotachysterol USP Dihydrotachysterol-2 / DHT2 9,10-SECOERGOSTA-5,7,22-TRIEN-3BETA-OL 9,10-SECOERGOSTA-5,7,22-TRIEN-3B-OL 7,22-trien-3-ol,(3-beta,5e,7e,10-alpha,22e)-10-secoergosta-5 7,22-trien-3-ol,(3beta,5e,7e,10alpha,22e)-10-secoergosta-5 anti-tetanysubstance10 dht(sub2) dht2 dihydral dihydro-tachystero dihydrotachysterol(sub2) dygratyl hytakerol parterol tachystin DICHYSTROLUM DIHYDROTACHYSTEROL CALCAMINE AT-10 ANTITANIL dihydrotachysterol crystalline 9,10-secoergosta-5,7,22-trien-3β-ol Cyclohexanol, 4-methyl-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-, (1S,3E,4S)- (1S,4S,E)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylcyclohexanol Dihydrotachysterol USP/EP/BP Dihydrotachysterol (1204000) HSDB 3314 HSDB3314 HSDB-3314 67-96-9 Analytical Standards Analytical Chromatography Product Catalog Alphabetic DID - DIN Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals